association of ccr5-59029 a/g and ccr2-v64i variants with renal allograft survival

background: despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. objective: the aim of current investigation was to study the impact of polymor-phisms of ccr5δ32, ccr5- 59029 a/g and ccr2-v64i on renal allograft survival. methods: using pcr and pcr-rflp methods in 84 renal transplant recipients, the influ-ence of ccr5δ32, ccr5- 59029 a/g and ccr2-v64i polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years. results: significant reductions were found in the risk of renal transplant rejection in recipients possessing the ccr2-64i (a) allele (p=0.03) or 59029-a allele (p=0.03) compared to non-rejector group. there were no significant differences in the fre-quency of ccr5δ32 polymorphism in rejector group compared to non-rejector group (p>0.05). conclusion: it was possible to conclude that the chemokine receptors ccr2-v64i (a) and ccr5- 59029 a alleles may influence renal allograft survival.